At present, premature ejaculation drug treatment is mainly 5-hydroxytryptamine reuptake inhibitors, topical anesthetics and so on. 1. 5-hydroxytryptamine reuptake inhibitors: the domestic marketed are dapoxetine, fluoxetine, fluvoxamine, paroxetine, oral 3 hours before sex, can prolong the ejaculatory latency. Common adverse reactions to dapoxetine include mild, transient diarrhea, vomiting, headache and dizziness. Also the co-administration of alcohol may exacerbate adverse reactions of the neurovascular system (e.g. syncope), and therefore increase the risk of accidental injury, so it is recommended that patients avoid alcohol while taking this product. 2. Topical anesthetics: commonly used compound lidocaine cream, procaine-lidocaine gel paste, dacronine hydrochloride. Local anesthetics by reducing the sensitivity of the head of the penis, reduce the excitement transmitted from the penis to the brain, prolong the ejaculation latency, suitable for people with sensitive penile sensation. However, local topical anesthetics dosage is likely to lead to the inability to get an erection, and not wearing a condom is likely to lead to numbness of the vaginal wall of the spouse. Please use the medication under the guidance of a doctor to be pharmacist, do not buy and take on your own, so as not to cause adverse reactions.