On the basis of retrograde cholangiopancreatography (ERCP), interventions such as duodenal papillary sphincterotomy (EST), endoscopic nasobiliary drainage (ENBD), and endoscopic internal biliary drainage (ERBD), i.e., ERCP surgery, can be performed. The disadvantages after ERCP surgery include conditions such as bleeding, postoperative pancreatitis, postoperative cholangitis, and other injuries. 1. Bleeding: It refers to the bleeding from the incision site, which is caused by the papillary injury and bile duct rupture during the operation. If the bleeding is relatively large, it can be intervened after the operation to stop the bleeding, or even open the abdomen to stop the bleeding. 2. Pancreatitis: Pancreatitis occurs after ERCP lithotripsy, it can be treated by fasting and drugs to inhibit pancreatic enzyme secretion, and most of the patients can get a good recovery. 3. Postoperative cholangitis: If patients have abdominal pain and jaundice after ERCP, postoperative cholangitis is suspected, and the risk of postoperative cholangitis can be prevented by placing nasobiliary drainage. 4. Other rare complications include rupture of pseudopancreatic cyst, severe pain in the upper abdomen and abdominal distension. After ERCP surgery, we should pay attention to the observation of postoperative complications, and if there is any discomfort, we should reflect it to the medical staff in time and treat it accordingly.