The skull plays the role of protecting and supporting the brain, sensory organs, and the starting parts of digestive and respiratory organs. If a defect occurs, it can bring a series of neurological symptoms to patients, such as severe headache, vertigo, easy fatigue, irritability, memory loss, depression, and decreased tolerance to vibration and sound. Therefore, when a patient has a skull defect, skull repair surgery should be done as early as possible. If the diameter of cranial defect is >3cm, cranial defect is an obstacle to aesthetics, and cranial defect has related clinical symptoms, such as dizziness, headache and other symptoms or psychological burden affecting life and work, cranial repair surgery should be done as early as possible. The timing of cranial defect repair surgery, patients who have no contraindications to surgery, as long as the condition allows, advocate early cranial repair and shaping, early cranial repair and shaping refers to the time less than three months. We use PEEK material for skull repair surgery, and have a wealth of clinical experience, and through a large number of cases to confirm that PEEK material for skull repair does not affect the postoperative medical examination. PEEK material is the best material for cranial repair. PEEK is slightly more expensive than traditional repair materials, but most patients can afford it.