Thermotherapy is useful for multiple nodules in the liver. Thermotherapy refers to radiofrequency ablation and microwave ablation. The specific operation method of radiofrequency ablation is to insert electrodes into liver cancer tissues under ultrasound or open conditions, and destroy the lesion tissues by using various physical methods, such as the thermal effect of electric current, and then achieve the purpose of reducing the tumor load. The principle of microwave ablation and radiofrequency ablation is almost the same, also the microwave probe is inserted inside the nodule, and the thermal energy generated by microwave is used to destroy the tumor, so as to achieve the purpose of inhibiting the growth of the tumor, and to make the tumor load of the tumor patients reduced. Both radiofrequency ablation and microwave ablation are minimally invasive treatments, featuring less damage to the patient and faster recovery. Hyperthermia is useful for intrahepatic multiple nodules, but over-execution of hyperthermia can lead to more liver-destroying tissues and risk of liver failure. Therefore, patients with multiple nodules in the liver should go to the hospital in time for regular treatment under the guidance of doctors.