Mast cell pigmented urticaria can be treated with oral medication, application of medication and injection of medication under the supervision of a doctor. 1. Oral medication: Mast cell pigmented urticaria is a benign mast cell hyperplasia, which refers to the skin reaction caused by the release of various mediators from mast cells, and the patient’s skin will appear red or brownish-red papules. Oral antihistamines can be taken, such as chlorpheniramine maleate tablets, levocetirizine hydrochloride tablets, etc., can play an anti-allergic role. 2. Apply drugs: If the skin has severe itching and pain, you can apply topical dexamethasone acetate cream, tretinoin econazole cream and other medications, which can play an anti-inflammatory role in relieving itching. 3. Injectable drugs: patients with serious conditions also need intravenous injection of glucocorticoid drugs, such as dexamethasone sodium phosphate injection, methylprednisolone sodium succinate and other drug therapy. It is recommended that patients with mast cell pigmented urticaria to the hospital, follow the doctor’s instructions for treatment, during the treatment period to do a good job of skin cleaning, avoid eating spicy and irritating food, so as not to affect the patient’s recovery.