Freckles are yellowish-brown pigmented spots on the sun-exposed skin of young and middle-aged women, and severe family aggregation of freckles may be related to autosomal dominant inheritance. Clinical manifestations Most commonly seen in children around 5 years old, mostly females. It is often aggravated in spring and summer and reduced in autumn and winter. It is usually found on the face (especially on the nose), but also on the shoulders and back. The typical lesions are light brown to yellowish brown pinpoint to rice-grain-sized spots, isolated and not fused with each other, varying in number and symmetrical in distribution, and the lesions become larger after ultraviolet radiation, while the color deepens and the number increases. Generally no conscious symptoms. Treatment: Avoid sun exposure and use external shading agent when going out. Melasma is a pigmented skin disease mostly found in the face of young and middle-aged women. Etiology and pathogenesis Ultraviolet radiation, use of cosmetics, pregnancy, endocrine disorders, drugs (contraceptives, chlorpromazine, phenytoin sodium, etc.), imbalance of trace elements, etc. can cause chloasma, among which pregnancy is also called gestation spot, which is related to the increase of estrogen level and can disappear after delivery; certain chronic diseases (such as gynecological diseases, hepatitis, chronic alcoholism, hyperthyroidism, tuberculosis, visceral tumors, etc.) can also occur. It may also occur in patients with certain chronic diseases (such as gynecological diseases, hepatitis, chronic alcoholism, hyperthyroidism, tuberculosis, tumors, etc.). Clinical manifestations Mostly affects young and middle-aged women, but can also occur in men. It often worsens in spring and summer and decreases in autumn and winter. It occurs symmetrically on the cheek area of the face in a butterfly shape, and may also involve the forehead, nose, and perioral area. Typical lesions are yellowish-brown or dark brown patches of varying sizes with clear edges. There are no conscious symptoms. The duration of the disease is variable and can last for months or years. Treatment First of all, we should look for the cause of the disease and treat it accordingly; avoid sun exposure, and use external shading agent on the face when going out in spring and summer. For pigmented skin diseases such as freckles and chloasma, medication or laser can be used to remove the spots according to the need and specific conditions. We have treated dozens of cases of freckles, chloasma and pigmentation spots with triple therapy and combination of Chinese and Western medicine and topical drugs, and the overall effect is satisfactory and worthy of clinical application. In addition, our hospital has caused the new “Feiton” laser and “black face doll” imported from Belgium, which have relatively satisfactory effect on pigmentation diseases.