In the clinic, patients often ask: Doctor, will I grow old after my hysterectomy? To answer this question, let’s first understand what role does the uterus play in the human body? The uterus is shaped like an inverted pear and is a hollow organ, which is the place where the embryo grows and develops. In women who have children, menstrual blood is also shed through the endometrium every month, so there are women who worry that once they don’t have menstruation, they will immediately become old. In fact, the control of menstrual flow is regulated by the human brain and ovaries, and the uterus is merely carrying out their orders. The brain regularly sends information to the ovaries, which then regularly release hormones to regulate the uterus to complete its physiological functions, such as conceiving a baby, menstruation and so on. Therefore, the removal of a diseased uterus has no short-term effect on human aging. However, in the long run, removal of the uterus will have some impact on the endocrine function of the body, especially the ovarian function. Anatomically speaking, the ovaries have two blood supply systems, one of which is from the uterus, although it only accounts for 30%, but once the uterus is removed, the blood supply to the ovaries will be reduced by 30%, which will not affect the ovarian function for a short time, but over time, the ovaries will become ischemic and will fail prematurely. Therefore, we are still very cautious about hysterectomy, and generally recommend hysterectomy only after the patient is 45 years old and has indications for hysterectomy.