Unbearable abdominal pain may be caused by appendicitis, urinary stones, gallbladder diseases, stomach diseases, pancreatic diseases, female gynecological diseases and other reasons. 1. Appendicitis: acute inflammation of the appendix causes unbearable abdominal pain, the pain is usually in the right lower abdomen, accompanied by pressure pain, nausea, vomiting and other symptoms. 2. Urinary stones: such as ureteral stones, kidney stones, in the acute attack can lead to abdominal pain. 3. Gallbladder diseases: most commonly seen in cholecystitis, cholelithiasis acute attack, causing unbearable pain in the right upper abdomen, accompanied by nausea, vomiting and other symptoms. 4. Stomach diseases: mostly seen in gastritis, peptic ulcer, etc. The pain is usually in the left upper abdomen, accompanied by acid reflux, heartburn, nausea and other symptoms. 5. Pancreatic diseases: such as acute pancreatitis, pancreatic cancer, can lead to intolerable pain in the left upper abdomen. 6. Female gynecological diseases: for example, tubal torsion, ovarian lesions, pelvic inflammatory disease, etc. can cause intolerable pain in the lower right abdomen. The pain in the abdomen is intolerable, it is recommended to consult a doctor in a timely manner, to clarify the cause of the disease and follow the doctor’s instructions for treatment.