Hunger in the middle of the night may be caused by physiological factors, such as not eating enough dinner, and pathological factors, such as hyperthyroidism, diabetes, etc.. 1. Physiological factors are more common reasons for not eating dinner or not eating enough dinner, can not normally provide the body with the energy it needs, so it is recommended to develop good eating habits. 2. Pathological factors: (1) hyperthyroidism: that is, hyperthyroidism, the patient’s thyroid hormone secretion is too much, resulting in the patient’s body to appear high level and high metabolic state, energy is quickly consumed, which will lead to the phenomenon of hunger in the middle of the night. (2) Diabetes mellitus: the patient’s body has insufficient insulin secretion or insulin resistance, and glucose cannot be broken down and absorbed. In order to obtain energy, it will further break down protein and fat, which will consume more to the human body, thus resulting in hunger in the middle of the night. Improper use of hypoglycemic drugs in the treatment, excessive use of medication leads to a substantial reduction in blood glucose, unable to provide energy for the body, will also appear in the middle of the night hunger phenomenon. (3) Diseases of the digestive system, such as gastric ulcers, can also affect the body’s intake and utilization of energy, resulting in midnight hunger. Repeatedly in the middle of the night will be hungry, it is recommended to go to the regular hospital, improve the relevant examination to clarify the cause of the disease, targeted treatment.