Girls with high estrogen may be prone to breast nodules. Estrogen, also known as female hormone, is mainly secreted by a girl’s ovaries and can promote the development of her secondary sexual characteristics; usually when estrogen is secreted in excess, resulting in its high level, it may lead to increased incidence of diseases such as uterine fibroids, breast cancer, menstrual irregularities, and so on. Breast nodules are mainly caused by diseases such as breast infection, fat necrosis, fibroadenoma, malignant tumors, intraductal papilloma, etc.; and breast cancer may belong to a type of malignant tumors, therefore, girls with excessive estrogen have an increased risk of malignant tumors such as breast cancer and may be prone to breast nodules. When high estrogen occurs, it is recommended to go to the hospital in time to consult the doctor and standardize the treatment as soon as possible.