α1microglobulin 19.3mg/L is usually more serious if it is seen in acute and chronic glomerulonephritis, nephrotic syndrome and other pathologic factors, while it is usually less serious if it is seen in physiologic factors such as consuming a large amount of high-protein diet and strenuous exercise. 1. Pathological factors: α1 microglobulin 19.3mg/L is usually more serious when it is seen in acute and chronic glomerulonephritis, nephrotic syndrome, diabetic nephropathy, hypertensive nephropathy, IgA nephropathy and other renal diseases, which need to be consulted in time in order not to aggravate the condition. 2. Physiological factors: If it is found in a large amount of high protein diet, strenuous exercise, cold, emotional stress, fatigue, etc., it is not too serious, and can be restored to the normal level automatically after eliminating the triggers. If α1 microglobulin is found to be abnormal, it is recommended to consult a doctor in time and follow the doctor’s instructions to standardize the diagnosis and treatment.