Nephrotic syndrome if combined with hyperuricemia can take febuxostat, severe renal insufficiency patients with caution. Febuxostat is not a drug for the treatment of nephrotic syndrome, the drug is suitable for long-term treatment of hyperuricemia in gout patients. Patients with mild or moderate renal insufficiency (creatinine clearance of 30-89 ml/min) need no dosage adjustment for febuxostat; febuxostat should be used with caution in patients with severe renal insufficiency, i.e. creatinine clearance of less than 30 ml/min. If progressive hepatic or renal impairment, anemia, angina pectoris, deafness, gastrointestinal discomfort occurs during the administration of the drug, it is recommended to stop the use of the drug and go to the hospital; the use of the drug is prohibited for those who are allergic to the drug, or who are being treated with drugs such as azathioprine or mercaptopurine. Caution is advised during pregnancy, breastfeeding, and for children under 18 years of age. Patients with nephrotic syndrome combined with hyperuricemia should go to the hospital in time and take Febuxostat and other medicines under the guidance of clinicians, do not take medicines by yourself.