Every part of the human body has its own role and is indispensable for human health, such as the skull, which is like an umbrella for the brain, ensuring the normal functioning of all life activities in the skull. However, life is full of hidden dangers, and sudden accidents that lead to skull defects need to be taken seriously. When the skull is missing, the intracranial tissues will naturally lose the “shelter” of the skull, the intracranial environment will change, the cerebrospinal fluid circulation and blood circulation of the brain will be affected, and in addition, it will also affect the neurological function, resulting in a series of craniosynostosis syndromes, which will affect the quality of life of the patients. What are the manifestations of craniosynostosis syndrome? The specific manifestations of craniosynostosis syndrome may include dizziness and headache, numbness and weakness of limbs, irritability, easy to be provoked, and some patients may be combined with visual impairment and hearing impairment, and in severe cases, seizures, which will affect the patient’s life and work. In addition to these, cranial defects seriously affect the image, but also to the patient’s psychological impact, and long time cranial defects are not repaired, if the impact of sharp objects again, it is very likely to damage the brain tissue, and even life-threatening. Therefore, skull defects should not be ignored, and it is necessary to go to the hospital in time to do skull repair surgery. In the cranial bone repair problem, we use the new polyether ether ketone peek material to carry out the comprehensive peek cranial bone repair plastic surgery, which is a very safe polymer material, all the performance is very good, not only highly restore the cranial anatomy, the postoperative effect is very beautiful, but also can be very good to improve some of the symptoms of cranial bone defect syndrome.