If you are only having Down’s syndrome screening, you can eat normally the night before, not too fatty. If you are having a liver or kidney function test or a lipid test at the same time as the Down’s syndrome screening, you should not eat after 10:00 pm the night before. The Down’s syndrome screening is a routine part of the maternity checkup, and usually a number of tests can be done after one blood draw, such as liver function, kidney function, and lipid tests at the same time as the blood draw. If the next day’s blood draw is only for Down’s syndrome screening and no other blood tests are performed, you can eat the night before. The main focus is on light and well-digested food, such as soup noodles, rice porridge, vegetables, etc., to avoid a high-fat diet affecting the separation of serum.