High thyrotropin alone may be subclinical hypothyroidism, etc., and requires temporary observation or medication depending on its cause. For patients with TSH >10 μIU/ml, it is appropriate to use low-dose levothyroxine to keep TSH at 0.3-3.0 μIU/ml. There is disagreement about replacement therapy for patients with elevated TSH but not more than 10 μIU/ml, but it is generally believed that those with thyroid autoantibody positivity or (and) goitre should also be treated. Thyroid hormone therapy should be given if the patient has symptoms of hypothyroidism, positive TPOAb, dyslipidemia, or atherosclerotic disease; if the patient does not have any of the above conditions, regular monitoring of TSH changes should be performed under medical supervision. For high thyroid stimulating hormone alone, it is recommended to identify the cause and follow the doctor’s instructions.