Helicobacter pylori fever two hours after taking medication, may be due to drug allergy, may also be caused by colds, it is recommended to stop the drug immediately or take aspirin and other antipyretic drugs. 1. drug allergy: Helicobacter pylori is a class of micro aerobic bacteria, often causing gastritis, peptic ulcers and so on. Generally, the main treatment program is the “quadruple method”, i.e. a proton pump inhibitor such as omeprazole + a bismuth such as bismuth pectin + two antibiotics such as amoxicillin, clarithromycin for eradication treatment. People who are allergic to the components of the drug may have adverse reactions such as skin rashes, and may also experience symptoms of elevated body temperature. 2. Cold: fever after taking the drug may also be caused by upper respiratory tract infection, in which case it can be treated symptomatically by taking antipyretic drugs such as aspirin. It should be noted that such drugs may cause nausea and vomiting and other adverse symptoms, may also aggravate peptic ulcer. The use of this drug is contraindicated in patients with bleeding disorders. If a person infected with Helicobacter pylori develops a fever after taking the appropriate medication, he or she must stop taking the medication and go to the hospital immediately for diagnosis and follow the doctor’s instructions for treatment, and must not take the medication on his or her own in order to avoid aggravation of the symptoms by drug interactions.