Small doses of aspirin should be used as a basic medication for diabetic patients Aspirin has been used for more than 100 years, it is a good antipyretic and analgesic drug, also has an extremely important role in the prevention of cardiovascular disease, it can reduce the risk of myocardial infarction, cerebral infarction and death, is the “cornerstone” of the prevention of cardiovascular disease “It is the cornerstone of the prevention and treatment of cardiovascular diseases. As an inhibitor of cyclooxygenase, aspirin mainly plays an anti-platelet aggregation role by reducing the synthesis of thromboxane A2, thus preventing thrombus formation and thus playing a role in preventing myocardial infarction, cerebral infarction and other thrombotic diseases. The risk of cardiovascular and cerebrovascular diseases is significantly higher in diabetic patients than in non-diabetic patients, and diabetes is classified as an equivocal risk for coronary heart disease. Numerous clinical studies both at home and abroad support that low-dose aspirin should be used as a basic medication for diabetic patients if there are no contraindications. Aspirin therapy should be started early in diabetic patients with one of the following risk factors: family history of early-onset coronary heart disease (men <55 years old, women <65 years old), smoking, hypertension, dyslipidemia, overweight or obesity, proteinuria, and history of myocardial infarction, stroke or transient ischemic attack, and peripheral vascular disease. The optimal dose of aspirin to prevent cardiovascular events is: 75 to 150 mg per day. Dosing frequency: once a day. Dosing time: generally taken at night. Because the body is less active at night, the blood is sticky and platelets are easily aggregated, so it is generally recommended to take it at night. Dosing regimen: In patients with cardiovascular and cerebrovascular diseases and high-risk factors, small doses of aspirin should be used for life if there are no contraindications. Interruption of aspirin therapy will rapidly increase the risk of cardiovascular and cerebrovascular events to their original levels, so the longer aspirin is taken, the greater the survival benefit. Clinical use of aspirin should also be noted for its adverse effects. The most common adverse reactions to aspirin are gastrointestinal irritation and bleeding. Therefore, in patients with bleeding tendencies or the presence of gastrointestinal disorders, attention should be paid to gastric mucosal damage and gastrointestinal bleeding when using aspirin. Also do not use aspirin in patients who are allergic to aspirin, have a history of asthma, have recent gastrointestinal bleeding, and have active liver disease. The use of aspirin in people younger than 21 years of age increases the risk of Reye's syndrome (a rare childhood disease that occurs after chickenpox and viral upper respiratory infections), so aspirin therapy is not recommended for this group of patients. In addition aspirin may increase the risk of cerebral hemorrhage in patients with hypertension whose blood pressure is not well controlled. Aspirin is a drug whose benefits far outweigh its risks, and the risk of bleeding from aspirin alone is only 2 in 10,000. Aspirin is available in regular and enteric tablets. Enteric tablets are not released in the stomach, but slowly in the small intestine, which effectively reduces irritation of the gastrointestinal tract. In patients at high cardiovascular risk with a history of ulcer bleeding, aspirin combined with a proton pump inhibitor can significantly reduce the symptoms of gastrointestinal irritation and bleeding side effects.