Progressive muscular osteogenesis imperfecta is a rare dominant genetic disorder. It is simply a genetic disorder that causes disorders in the growth, repair, and shaping of bone tissue. The disease usually starts in the center of the body and gradually affects the neck, back, pelvis, limbs and other parts of the body, resulting in the gradual deformation of various parts of the body, the growth of new bone in soft tissues such as muscles and tendons, and the gradual stiffening of the body, losing the activity and function of the original tissues, which may ultimately result in the gradual loss of mobility, or even lead to death. However, this disease only affects the soft tissues of the locomotor system, such as muscles and ligaments, and ossification does not occur in organs such as the heart and brain tissue. Due to the bleeding and damage caused during surgery, the surgical site can become ossified within a short period of time, which means that the more surgery is performed, the more ossified the site becomes and the more severe it becomes. Therefore, there is no particularly effective solution for this disease, only symptomatic treatment to ensure the safety of the vital system.