Papillomatous neoplasm in the lateral wall of the epiglottis may be benign or malignant, and the nature of the lesion needs to be clarified first, and targeted treatment including surgery, medication, and radiotherapy should be taken. When a papilloma is found in the lateral wall of the epiglottis, surface anesthesia is recommended because it is difficult to determine the nature of the lesion. After resection, the nature of the mass can be clarified according to the results of pathological examination. Pathological examination suggests squamous epithelial papilloma, mostly human papillomavirus infection, need to carry out viral testing and typing, complete surgical resection of the mass, you can use interferon and other treatments, and pay attention to the dynamic monitoring of the condition, to determine whether there is a recurrence of the possibility. If it is a malignant tumor, it is necessary to expand the surgical scope of resection according to the results of pathological examination until the margins are negative, while postoperative radiotherapy is carried out. If papillary neoplasm is found in the lateral wall of epiglottis, it is necessary to consult otolaryngology department of regular hospital for systematic examination and diagnosis, and follow the doctor’s instructions to standardize the medication and treatment.