Valsartan amlodipine after taking a small number of patients will have creatinine elevation phenomenon, so for the application of high-risk patients, attention should be paid to review the blood creatinine level. The drug belongs to the compound preparation, in which the antihypertensive of valsartan is through the renin-angiotensin-aldosterone system to regulate the glomerulus to make its filtration rate decrease, which has a certain degree of damage to renal function; normal people are generally unaffected, and if there is renal artery stenosis, the creatinine can be elevated. Common adverse reactions to the drug include dizziness, headache, abdominal pain, diarrhea, fatigue, limb pain, dry cough and facial edema. It is contraindicated in patients who are allergic to the active ingredient or any of the excipients, pregnant and lactating women, patients with hereditary angioedema, and patients who have developed angioedema early in the treatment with angiotensin-converting enzyme inhibitors or angiotensin II receptor antagonists. If there is any discomfort, it is recommended that the patient go to a regular hospital for consultation and treatment, and not blindly take or stop the drug to avoid delaying the condition.