In the process of taking medication for rheumatoid, depending on the actual need, some medications are actually sometimes used to alleviate the side effects or prevent them from appearing. The questions of why and how to use them sometimes make us feel confused, so here I will try to make some summaries for reference. Folic acid is a drug used to reduce and prevent the side effects of methotrexate. Folic acid can competitively reduce the absorption of methotrexate, so it can reduce the absorption of methotrexate and reduce its damage to normal cells. Sometimes patients are not very clear about the timing and dosage of their doses. In general, relatively low methotrexate doses, such as 7.5 mg per week, can be used without folic acid. Folic acid is only used when methotrexate is used in higher doses. There are different clinical approaches regarding the dose of folic acid to be taken. There are two more common ones: one is to take a dose of folic acid, comparable to methotrexate, the day after taking methotrexate, once a week. The other, 1 mg of folic acid per day, is a routine folic acid supplement in the United States and is now being used to prevent side effects of methotrexate. Other doctors say that there are patients in Australia who use 0.5 mg of folic acid daily, and this may be related to the dose of methotrexate used by the patient, how well the patient tolerates methotrexate, etc. That said, rheumatoid treatment, individualized medication is an increasingly important issue for clinicians, therefore, the specific situation is analyzed, we patients can not blindly follow. Second: liver protection and liver-protective drugs If there is an elevation of transaminases, liver-protective drugs will be used, and they are used differently in different cases. If it is an early case of transient aminotransferase elevation, liver-protective drugs can be stopped as the body becomes more adaptable to the drugs, and these drugs, too, are not the more the better. Some people may feel that taking liver protection drugs during the period of taking rheumatoid drugs may play a role in protecting the liver, this is generally taken for granted. Many studies have not gone into the molecular and cellular fields, and we are not clear about the mechanism of the damage caused by drugs to the liver, therefore, if liver-protective drugs and immunosuppressants are taken at the same time, can we avoid the damage of immunosuppressants to the liver, this is something that has not been studied and no clinical conclusions have been drawn; and liver-protective drugs, as drugs themselves may also exist for the liver, kidney damage. kidney damage. Therefore, our patients should not use liver-protective drugs on their own for a long time. If liver damage caused by long-term use of immunosuppressive drugs, we often need to stop taking immunosuppressive drugs, or at least adjust the use of immunosuppressive drugs, after recovery from liver damage, also need to stop taking liver-protective drugs, not always use, in the end how to use, as patients we may not have that ability to figure out, need the guidance of doctors. Third: elevated white blood cells class of drugs For the use of such drugs, generally can be imitated liver protection class of drugs, to achieve the purpose, that is, white blood cells back up, stable, then you can stop. Some of them are vitamin drugs, which can be used appropriately as nutritional supplements. Fourth: drugs to protect the gastric mucosa non-steroidal anti-inflammatory drugs, often may cause damage to the gastric mucosa, the clinical use of some drugs to prevent side effects, common is omeprazole magnesium enteric dissolve tablets, ranitidine, morpholine, etc.. The main ingredient of omeprazole magnesium enteric dissolve tablets is omeprazole magnesium, which is an antacid over-the-counter drug. Omeprazole can inhibit the secretion of gastric acid and is clinically used for heartburn and acid reflux caused by excessive gastric acid. Ranitidine is an H-proton antagonist, also an antacid, decreases gastric acid and gastric enzyme activity, and is mainly used for the treatment of excessive gastric acid and heartburn. Morpholine is a gastrointestinal motility drug that increases gastric motility and treats indigestion caused by insufficient gastric motility. NSAIDs, may lead to the occurrence of gastric ulcer or gastric mucosal erosion associated with them. Therefore, NSAIDs are used clinically to prevent NSAID-related gastric ulcer, gastric mucosal erosion or dyspepsia symptoms, especially when gastric discomfort symptoms occur, using drugs such as omeprazole enteric coated tablets. In principle, long-term use of NSAIDs in the treatment of rheumatoid is not advocated, and after the immunosuppressants have worked and inflammatory activity has been controlled, there is no need to be using such substances. Drugs for the protection of the stomach and the treatment of gastric disorders are used, depending on the situation. In conclusion, the issue in a nutshell is that regular treatment of the disease is the way to go. Even patients who have been sick for a long time cannot become doctors, or even their own treating doctors, and it is not just about the side effects. We, the patients, sometimes need to let go of our blind arrogance. How many problems are actually caused by our negligence, our laziness to go to the hospital, our distrust of doctors, our naivety that we think we can “see the whole picture” and ignore the nature of the scientific system of medicine.