1.Liver biopsy is the gold standard for diagnosing liver fibrosis, and can accurately and timely determine the degree of liver fibrosis; when liver tissue fibrosis is in S2,S3, the anti-liver fibrosis treatment is more effective. 2.According to the ultrasound report, if we see that the liver envelope is not (less) smooth, rough, grid-like in the liver, unclear vascular direction and other descriptions, we can determine that there is already fibrosis, but the degree may already be heavy, at this time, anti-liver fibrosis treatment is not too early. 3.Refer to the serological liver fibrosis “four” indicators, namely serum hyaluronic acid (HA), type III pre-collagen peptide (P-III-P), type IV collagen (IV-C) and laminin (LN), if higher than the normal reference value can be considered the existence of liver fibrosis, but serological indicators are not completely with However, serological indicators do not correspond exactly to the pathological changes of liver fibrosis.