Condyloma acuminatum has a high clinical recurrence rate, and the exact factors that lead to recurrence are not fully understood. There are many factors that can lead to the recurrence of the disease. The majority of patients will be completely cured after regular treatment and will not recur. Possible recurrence factors are: 1, there may be a certain genetic susceptibility, such as a significant increase in HLA-A10 reported for this disease. 2. low cellular immune function; 3. presence of HPV subclinical infection 4. local inflammation or complications 5. moist local environment, such as in the foreskin, urethra, around the anus, and cervical area. 6, Pregnancy. 7, incomplete treatment of sexual partners Treatment of the disease should take comprehensive preventive and control measures, the prevention and treatment principles are to improve individual immunity, treatment of complications, the most important is the treatment of HPV subclinical infection and latent lesions, keep the local clean and dry . Follow-up treatment. 1.Enhance the immunity of the body 2.Treatment of HPV subclinical infection, photodynamic therapy is preferred. 3.Topical antiviral agents 4.Careful treatment of complications. 5, pay attention to keep the local clean, dry. 6, tracking treatment: this is very important, the male themselves to find, such as suspicious recurrence, immediately come to the hospital for treatment; women in the treatment of 3 months after regular review, most patients after several treatments, that is, no longer have warts appear, clinical cure. 7, sexual partners at the same time treatment