Leg skin roughness is not smooth, need to be based on the cause of the use of medication, common causes include ichthyosis, keratosis pilaris and so on. 1. Ichthyosis: it occurs on the extensor side of the limbs and the back, and usually has no self-conscious symptoms. Typical lesions are light brown to dark brown rhombic or polygonal scales, the scales are centralized and fixed, peripheral warping, such as fish scale. Topical 10% to 20% urea cream can be used to increase the degree of skin hydration. Vitamin A cream can improve keratinization and reduce scales. 2. Keratosis pilaris: it occurs on the outer side of the upper arm and the anterior side of the thigh, mainly manifested as rough skin, the surface of light red or normal skin color pimples, chicken skin-like appearance. Local topical retinoic acid cream, tazarotene gel, etc., skin lesions with severe symptoms, can be combined with oral vitamin A, vitamin E to improve the symptoms. All of the above drugs have adverse reactions and are recommended to be used under the guidance of a doctor. Rough skin on the legs may also have other causes, it is recommended to go to the hospital in a timely manner to improve the examination, to clarify the cause of the disease to give targeted treatment.