Positive leukocyte esterase in routine urine examination usually suggests the manifestation of urinary tract infection, which needs to pay attention to rest, and at the same time, cooperate with antibiotics and other medicines to carry on systematic treatment, but should pay attention to the existence of false positives. In routine urine examination, if the number of white blood cells in the urine is high, leukocyte esterase can appear positive, representing the existence of bacterial infection of the urinary tract, often accompanied by frequent urination, urinary urgency, urinary pain and other symptoms. After the diagnosis is confirmed, attention should be paid to rest, timely supplementation of nutrients and water, and the need for adequate use of medication, commonly used broad-spectrum antibiotics, such as levofloxacin and other treatments. It is worth noting that if a woman’s vaginal secretions contaminate the urine specimen during the examination, a false-positive result can occur, and there are no symptoms of urinary tract infection. At this time there is no urinary pain, urinary frequency and other symptoms of the examinee can review a routine urine examination, take clean mid-range urine. In short, the appearance of urine routine leukocyte esterase positive, should be timely to the hospital, under the guidance of the doctor for the next step in the diagnosis and treatment.