Generally, multiple small lymph nodes is a term used in imaging reports to refer to multiple enlarged lymph nodes found in the same location. Multiple small lymph nodes may be the result of lymphadenopathy, lymphoid tumors, viral infections, and other diseases. 1. Lymphadenitis: Lymphadenitis is an infection by pathogens such as bacteria, viruses, or Mycobacterium tuberculosis that results in reactive hyperplasia of nearby lymph nodes with inflammatory manifestations. These enlarged lymph nodes tend to be softer in texture, with good mobility and tenderness. 2. Lymphoma: Lymphoma refers to malignant tumors growing in the area of lymph nodes or lymphatic tissues. In the early stage, there may be painless enlarged lymph nodes and small lymph nodes, which need to be treated by surgical resection, but also need to be combined with radiotherapy treatment after surgery. It is also possible that the malignant tumor elsewhere has metastasized through lymphatic transfer, leading to enlargement of multiple invaded lymph nodes. It can also be caused by a variety of other diseases, which lead to multiple small lymph nodes. Therefore, we should consult the doctor in time, improve the examination, and follow the doctor’s instruction after clear diagnosis.