Doxepin, or doxepin hydrochloride tablets, and Sulpiride are two different medications, and they differ in terms of drug composition, clinical indications, and methods of administration. Doxepin hydrochloride tablets are used to treat depression and anxiety neurosis. Contraindications are severe heart disease, recent heart attack, epilepsy, glaucoma and so on. Adverse reactions such as drowsiness, excessive sweating and dry mouth can occur in the early stage of treatment. The main ingredient of Sulpiride is Sulpiride, the indications for apathy, withdrawal, rigidity, depression, hallucinations and delusional symptoms of the effect is better, for schizophrenia simple type, paranoid, nervous type and chronic schizophrenia withdrawn, withdrawn, apathetic symptoms; on the symptoms of depression has a certain efficacy; but also can be used as antinausea medication. Common adverse reactions to Sulpiride include insomnia, early awakening, headache, irritability and other anticholinergic adverse reactions; pyramidal system reactions can occur when the dose is too high. Contraindications are hypersensitivity to the product, patients with pituitary prolactin adenomas, and patients with hypertension. These two drugs are clinical prescription drugs, its indications and the use of the dose is not the same, the patient must be in a professional psychiatrist issued a prescription to follow the doctor’s instructions, not blindly used on their own, so as not to cause serious consequences.