Esomeprazole and paracetamol can be taken together. Paracetamol belongs to the antipyretic and analgesic drugs, which may cause gastric mucous membrane stimulation causing epigastric discomfort. Estemiprazole is a proton pump inhibitor, its role is to inhibit the secretion of gastric acid, reduce paracetamol damage to the gastric mucosa, relieve epigastric discomfort, the two drugs taken together usually do not produce drug interactions. Taking esomeprazole may cause headache, abdominal pain, diarrhea, nausea, vomiting, constipation, dermatitis, itching and other adverse reactions, allergic to the components of the drug is prohibited, pregnant, lactating women should be cautious. Paracetamol long-term overdose may cause liver cell necrosis, liver damage, neurological decompensation and other toxic side effects, pregnant women should be used with caution. It is recommended to take the above two drugs under the guidance of a physician, do not take on their own.