Monkeypox can be cured with timely and scientific treatment. Although monkeypox virus and smallpox virus belong to the genus Orthopoxvirus, which is pathogenic to humans, it is far less lethal than smallpox. Monkeypox is a self-limiting disease with a good prognosis for most patients. Severe cases are seen only in young children, immunocompromised people, and the current mortality rate is about 3% in the West African branch and 10% in the Congo Basin branch. Therefore, monkeypox is not hopeless, but treatment needs to be timely and scientific. Currently, the main treatment for monkeypox is symptomatic supportive treatment and complication treatment. For symptomatic supportive treatment, the main purpose is to regulate the patient’s rest, nutrition, maintain the patient’s body temperature, relieve the patient’s itching and pain due to the rash, and avoid a series of complications as much as possible during the symptomatic treatment. The main purpose of the treatment of complications is to alleviate the symptoms of encephalitis and secondary bacterial infections. For example, effective antibacterial drugs can be given to patients when secondary skin bacterial infection occurs; when encephalitis occurs, sedation, dehydration and lowering of cranial pressure, airway protection and other treatments are given. Once infected with monkeypox, the treatment should be actively standardized.