Stage II syphilis is when stage I syphilis is not completely treated, or not treated, and then spreads throughout the body by entering the bloodstream through the lymphatic system. It is usually 3-4 weeks after the hard chancre subsides, or 9-12 weeks after the infection. The first regimen is benzathine penicillin 2.4 million units, injected intramuscularly into both buttocks once a week for 2-3 times. The second option is procaine penicillin 800,000 units, injected intramuscularly once a day for 10-15 days. If penicillin is allergic, you can choose ceftriaxone sodium 1.0 g, IV daily for 14 days, or continuous oral tetracyclines, such as tetracycline 2.0 g/day, or doxycycline 200 m g/day, or memantine 200 m g/day for 15 days. There is also a regimen of continuous oral erythromycin medications, such as erythromycin 2.0 g/day for 15 days. Although all these drugs can treat early syphilis, the tetracyclines and erythromycins are less effective than the penicillins and are usually used as alternative treatment drugs for penicillin allergy.