Squamous epithelial papillomas are benign tumors, not malignant cancers, and are mostly caused by human papillomavirus, which requires medication, surgery, or physical therapy. Papillomas occurring in the squamous epithelium are benign tumors, not cancerous, and are mainly caused by human papillomavirus HPV infections, of which high-risk types 16 and 18 are more likely to cause the disease. Papilloma can occur in the perineum, around the genitals, the hilar and other parts of the body, mainly manifested as a localized rash, the color can be normal skin color or white, patchy distribution, may be accompanied by pain and itching and other symptoms. The treatment of squamous epithelial papilloma includes the use of fluorouracil ointment, dichloroacetic acid solution and other topical application, but it should be noted that pregnant women are prohibited, and follow the doctor’s instructions to use the drug. Meanwhile, it can be treated with surgical excision, carbon dioxide laser removal, cryoablation and other measures. When squamous epithelial papilloma appears, it is recommended to go to the hospital in time.