Roughness of intestinal mucosal surface may be caused by diseases such as enteritis and intestinal tumors. 1. Enteritis: such as proctitis, colitis and other diseases can appear the phenomenon of rough surface of intestinal mucosa, usually the intestinal mucosal changes found under colonoscopy, mostly accompanied by infiltration of inflammatory substances, which can be clinically manifested as diarrhea, abdominal pain, mucus stools, urgency and heaviness and other symptoms. 2. Intestinal tumor: intestinal tumor can also appear rough surface of intestinal mucosa under colonoscopy, and even the tumor can be observed to bulge into the intestinal lumen, which usually needs to be judged by pathological biopsy to determine its benign or malignant nature, and clinically manifested as mucus, pus and blood in stools, urgency, and then heaviness, and change of defecation habit. When the surface of intestinal mucosa is rough, it is recommended to consult a doctor in time, to clarify its pathological nature under the guidance of a professional physician, and to carry out targeted treatment.