The normal range of alanine aminotransferase is 0-40U/L, and 153U/L belongs to elevated aminotransferase, which suggests hepatocellular injury, and may be caused by viral hepatitis, alcoholic liver injury and drug liver injury. 1. Viral hepatitis: viral infections can easily lead to liver function damage, causing transaminase elevation, such as hepatitis B and C, etc., need to actively receive antiviral drug treatment, more common hepatitis B treatment drugs include entecavir and tenofovir, etc.; hepatitis C treatment drugs, mainly sofosbuvirvirvipitavir and so on. 2. Alcoholic liver injury: drinking alcohol can easily cause liver function damage and elevated aminotransferases, so it is necessary to actively quit drinking alcohol, and it can be given to liver-protecting drugs such as polyene phosphatidylcholine. 3. Pharmacological liver injury: long-term use of drugs is more harmful, may cause liver damage, need to stop taking the drug immediately. Elevated aminotransferases may also be related to liver and gallbladder inflammation, tumors, obesity and other factors, once elevated aminotransferases, it is recommended to consult a doctor in a timely manner, to clarify the cause of the disease, and actively treat it, so as to avoid delaying the condition.