The symptoms of sore knees after a cold are mainly due to the systemic immune response caused by the cold, resulting in the release of inflammatory mediators throughout the body, which leads to the symptoms of knee pain and muscle soreness. The main treatment for this condition is to treat the primary cause, and if the symptoms are not relieved at the same time, you must go to a regular hospital for routine blood tests. If it is caused by a viral infection, you can use non-steroidal anti-inflammatory and analgesic drugs to relieve knee pain, drink more water and rest more. If bacterial infection is detected in the joint fluid, antibiotics may be needed or surgery may be required to provide effective relief and cure the knee pain.