Weakly positive antibodies to Mycoplasma pneumoniae suggest a possible acute infection with Mycoplasma pneumoniae, which needs to be further ruled out in conjunction with the patient’s symptoms. 1. Weakly positive Mycoplasma pneumoniae may be a small amount of mycoplasma entering the patient’s organism causing infectious lesions if accompanied by fever, cough, sore throat, malaise, headache and nausea and vomiting. This means that the diagnosis of Mycoplasma pneumoniae is established. 2. Patients can follow the doctor’s instructions to use macrolide antibiotic drugs such as roxithromycin capsules and azithromycin capsules for treatment. If the cough is more severe, it can be combined with drugs such as Ambroxol hydrochloride tablets or Ambroxol oral solution. If the fever is high and the temperature exceeds 38.5℃, ibuprofen suspension is also needed to reduce the fever. When the patient has a weak positive antibody to Mycoplasma pneumoniae, he should go to the hospital in time, under the guidance of the doctor for proper treatment, to avoid delaying the disease and causing adverse consequences.