Mucosal erosion and stiffness in the anterior pyloric region are mostly caused by inflammation at the pylorus, which can be treated by adjusting lifestyle and diet, taking medication or surgery. 1. Adjustment of dietary habits: patients with mucosal erosion and rigidity in the anterior pyloric region should pay attention to their diet, avoid eating cold and spicy foods such as chili peppers, mustard and other indigestible foods such as deep-fried food, reduce the stimulation of the gastric mucosa, and maintain a light diet and balanced nutrition. Usually strengthen the appropriate exercise, ensure enough sleep, avoid staying up late, and enhance their physical condition. 2. Taking medicines: patients can take acid-suppressing drugs such as omeprazole, lansoprazole and ranitidine to reduce the secretion of gastric acid, and also take gastric mucosal protection drugs such as bismuth potassium citrate and magnesium aluminium carbonate to form a protective layer on the gastric mucosa, so as to alleviate the stimulation of the gastric mucosa by gastric acid and alleviate the condition. In addition, patients with Helicobacter pylori infection should take antibiotics such as amoxicillin, clarithromycin, norfloxacin and metronidazole at the same time for Helicobacter pylori eradication treatment. 3. Surgery: If the patient’s symptoms are severe, or bleeding or perforation occurs, surgery can be performed. When the patient has erosion and stiffness of the mucosa in the anterior pyloric region, it is recommended to consult a doctor in time and receive treatment actively. Drugs need to be taken in strict accordance with the doctor’s instructions, not self-medication, so as not to delay or even aggravate the condition.