Accumulation of fat into bulges in the calves may be caused by lipoma, sebaceous cysts, metastasis of malignant tumors and so on. General treatment or surgery should be chosen according to the cause. 1. Lipoma: patients with abnormal accumulation of fat in the calf can consider whether it is lipoma of the calf. If the volume of the lipoma is small and the patient does not have obvious symptoms, it is recommended to go to the hospital, and most of the clinical treatments are based on observation. If the size of lipoma gradually increases and there are complications such as swelling and pain, it should be treated by surgical excision. 2. Sebaceous cysts: Sebaceous cysts are usually caused by the obstruction of sebaceous excretory ducts of patients, and the lesions are often located in the skin or subcutaneous tissues, adherent to the skin, and mostly solitary. After diagnosis, the cyst should be removed surgically, and if it is complicated by infection, you can choose to carry out anti-infective treatment such as madecassicin before surgery. 3. Malignant tumor metastasis to the calf: patients such as bone tumor, soft tissue sarcoma metastasized to the calf tissue, can be due to tumor occupancy so that fat accumulation bulge. At this time, biopsy should be carried out as soon as possible, and if the bulge continues to increase, surgical resection should be considered. When the fat accumulates into bulge in the calf, it is recommended to determine the treatment method under the doctor’s diagnosis so as not to delay the condition.