Elevated bilirubin caused by hepatitis E is not life-threatening. If the bilirubin cannot be lowered for a long time, it is recommended to be hospitalized for relevant examinations to clarify the relevant causes and treat the cause. Normal bilirubin ranges from 3.4umol/L to 17.1umol/L (adults). When bilirubin is 400umol/L, which is more than 25 times the normal value, cholestasis and jaundice may occur. At this time, yellowing of the skin and yellowing of the sclera visible to the naked eye will occur. The treatment time will be longer and the recovery is slower. In daily life, you need to pay attention to diet, avoid eating too much protein, avoid smoking and alcohol, avoid staying up late, and increase the amount of exercise appropriately. When the bilirubin is too high, you need to carry out regular treatment under the guidance of the doctor, not self-medication, to avoid aggravating the condition.