The treatment of leukemia-induced upper sternal pressure pain includes medication for pain relief, anti-leukemia treatment and other treatment modalities. 1. Drugs for pain relief: drugs for pain relief can be taken under the guidance of doctors, such as non-steroidal drugs ibuprofen, weak opioids tramadol and so on, which have a good effect on pain relief. 2. Anti-leukemia treatment: leukemia cells proliferate a lot in the bone marrow cavity, resulting in excessive pressure in the bone marrow cavity, which is one of the causes of sternal pain in leukemia patients. Anti-leukemia treatment, such as combined chemotherapy and bone marrow transplantation, should be actively carried out to treat leukemia and at the same time relieve sternal pain. Pressing pain in the upper part of the sternum caused by leukemia should go to the hospital in time and be treated under the doctor’s guidance, and blind self-medication should be avoided.