The most important symptom when bone metastasis from cancer occurs is pain. After bone metastasis, there will be corresponding bone metastasis occurring pain. When it occurs in the spine, vertebrae and lumbar spine, in addition to lumbar spine pain, there are also lumbar nerves around, there will be lower limb pain called radicular pain, in addition to lumbar pain, there will be related invasion to the related innervation area lower limb pain. For example, in metastatic ribs, in addition to rib pain, there will be intercostal neuralgia, in metastatic cervical spine, in addition to neck pain, there will be upper limb nerve root radiating pain, in bone metastasis in myeloma, it is diffuse whole body bone metastasis whole body pain. The most common bone metastasis symptom is pain, and it tends to be moderate to severe pain.