Calcipotriol is not used as a first-line medication for vitiligo, so it does not cure vitiligo, but can be used to relieve symptoms. Calcipotriol is a topical skin medication that is usually used in the treatment of psoriasis. Through the use of topical preparations of the vitamin D derivative calcipotriol, it can inhibit the proliferation of skin cells and induce their differentiation, thus correcting the abnormalities of proliferation and differentiation of psoriatic lesions. Vitiligo is a disease in which the destruction of melanocytes leads to the appearance of white patches on the skin, especially in people with darker skin tones. Vitiligo is a chronic disease and in both cases mainly topical corticosteroid drugs are used, as well as the vitamin D3 derivative, calcipotriol, which improves the patient’s symptoms. It should be contraindicated in people who are allergic to any of the components in Calcipotriol, and in people with disorders of calcium metabolism. Common adverse reactions include pruritus, skin irritation, burning sensation, tingling sensation, dry skin, erythema and rash. Note that patients with severe renal failure or severe hepatic insufficiency should avoid the use of Darius. It is recommended that patients with vitiligo go to the hospital in time and use the medication under the doctor’s guidance, avoiding self-medication.