Mouth and nose sores are usually caused by herpes simplex virus infection. Drinking water can provide the body with moisture, which usually has no therapeutic effect on the disease, which can be treated by systemic antiviral therapy and local medication. 1. Systemic antiviral therapy: nucleoside antiviral drugs have strong anti-herpes simplex virus effects, including acyclovir, valacyclovir, famciclovir and so on. 2. Local medication: local medication for oral mucosal lesions can reduce inflammation and relieve pain, and promote healing, such as chlorhexidine gluconate solution gargle, acyclovir ointment topical rub, cidadex iodine tablets contained in the taking and so on. There may be other reasons for sores in the mouth and nose, so it is recommended to go to the hospital in time for early targeted treatment. All of the above medications should be used under the guidance of a doctor.