High glutamyltransferase may be seen when the liver is jeopardized by certain diseases, such as hepatitis, fatty liver, alcoholic liver, cirrhosis, and so on. Glutamyltransferase is found mainly in cell membranes and microsomes and is involved in the metabolism of glutathione. It is abundant in the kidney, liver and pancreas, and mainly originates from the hepatobiliary system, with a normal reference range of 11-50 U/L for men and 7-32 U/L for women. Serum glutamyltransferase is elevated when hepatic synthesis is hyperactive or bile excretion is blocked, and its elevation is commonly seen in biliary obstructive diseases, such as cholestasis due to primary biliary cirrhosis, sclerosing cholangitis, etc., and hepatocellular carcinoma. Elevated glutamyltransferase is also seen in acute and chronic viral hepatitis, cirrhosis, acute and chronic alcoholic hepatitis, drug-induced hepatitis, etc.; and also in fatty liver, pancreatitis, pancreatic tumor, etc. It is recommended to consult a doctor when you find high glutamyltransferase, and have the cause of elevated glutamyltransferase clarified by a professional doctor in combination with liver function, liver and gallbladder ultrasound and other tests, and actively diagnose and treat it, so as to avoid delaying the condition.