Negative antisperm antibodies generally mean that there are no antisperm antibodies present in the body, then there will be no immune sterility, which is normal. Anti-sperm antibodies are antibodies produced and secreted by lymphocytes that have the ability to kill sperm. They can be produced by both men and women. Under normal circumstances, sperm cannot come into contact with the bloodstream and will not stimulate the body to produce the corresponding antibodies. Once a man has a reproductive system injury, his semen may come into contact with the blood, and the lymphocytes in the blood may treat the sperm as a foreign antigen and produce an antigen-antibody immune response, which produces and secretes antibodies that can kill sperm, and these antibodies are called anti-sperm antibodies. If the semen enters the woman’s body after intercourse, and if the woman’s reproductive system has mucous membrane damage or broken capillaries, the sperm can also come into contact with the woman’s blood, which will also result in an antigen-antibody immune response and the production of anti-sperm antibodies. Negative antisperm antibodies indicate that the sperms have not come into contact with the blood, or that the woman does not produce antibodies against her husband’s sperms. If antisperm antibodies are positive, it is necessary to go for systematic treatment. If the patient is not feeling well, it is necessary to consult the doctor for examination and early treatment.