Minor triple yang patients with virus 6 times may be more serious, it is recommended to consult a doctor in time, combined with ultrasound, liver function and other indicators to analyze the condition, if necessary, under the guidance of the doctor to use tenofovir and other antiviral treatment. Clinically, the entire course of chronic hepatitis B can be divided into four phases, namely: immune tolerance, immune clearance, immune control and re-activation. Major triple positive refers to hepatitis B markers 1, 3, 5 positive, and minor triple positive is 1, 4, 5 positive, mostly due to the body’s immune or drug effects lead to the reduction of viral activity, from major triple positive to minor triple positive. However, if the hepatitis B virus DNA is elevated in combination with minor triple positive, often accompanied by elevated liver function indexes, liver fibrosis, etc., which is called e antigen-negative chronic hepatitis B, it suggests that the virus is active again, and it can also cause liver cirrhosis, hepatocellular carcinoma, etc., and it needs to be treated with antiviral therapy using drugs such as tenofovir or interferon. Therefore, the combination of virus 6 times in patients with small triple yang may also be more serious, it is recommended to seek medical treatment as soon as possible, active treatment, to avoid complications.