In the case of a 40-50 year old woman with paroxysmal hot flashes, perimenopausal syndrome may be the first thing to come to mind, which may be accompanied by a disruption of the menstrual cycle, or a state of amenorrhea. If the diagnosis at this point is indeed a menopausal state based on sex hormone levels, perimenopause, if the symptoms are particularly pronounced, can be evaluated to see if HRT hormone replacement therapy can be done. However, there may be other reasons, some patients have partial sweating, such as sweating on the hands called hand sweating, which may be related to sympathetic nerve abnormalities, and hand sweating can be resolved with minimally invasive neurological treatment. There are also diabetic patients with abnormal sweating, need to know whether there is diabetic autonomic neuropathy, this case may be segmental hemiplegia sweating. The basic treatment of autonomic neuropathy is to control blood glucose, and then nutritional nerve therapy to repair the nervous system. If the sweating is combined with panic attacks and hand tremors, hypoglycemia needs to be ruled out. In addition, if the sweating is combined with impatience, fluctuation, and dryness, it is necessary to identify whether there is a state of hyperthyroidism. There may also be night sweats, which need to be identified as a combination of other infections, such as tuberculosis.