High sex hormone binding globulin may be caused by high fat and fried foods that affect girls of school age, resulting in premature breast maturation and elevated sex hormone binding globulin. Some patients also suffer from anorexia nervosa due to frequent dieting and weight loss, which can also lead to high sex hormone binding globulin. In addition, there are several common causes: 1. Hyperthyroidism: High sex hormone binding globulin may be caused by hyperthyroidism, mainly due to the stimulation of thyroid hormones. Patients may have a variety of adverse reactions such as hyper-metabolism and sympathetic excitation, and may also be accompanied by palpitations, increased sweating and vision loss. 2. Liver diseases: the liver is the main place for human protein, and chronic hepatitis and cirrhosis can lead to abnormal protein synthesis and secretion in the human body, which can easily lead to high sex hormone binding globulin. 3. The abnormal hormone fluctuations may lead to endocrine disorders in the human body, resulting in an increase in sex hormone binding globulin.