Leukemia can cause a yellow face, but it is not always caused by leukemia. There are many causes of yellowing in children, most of them can be caused by jaundice, anemia, etc. It needs to be combined with other accompanying symptoms and tests to determine what causes it. Jaundice can cause yellowing of the skin and sclera, and the bilirubin level in the child’s body is high at this time, which requires blue light irradiation and even blood exchange in severe cases. Secondly, yellowing of the face of children due to anemia is also common, and the child may also show poor mental health and weakness, which requires routine blood tests in the pediatric department to clarify the diagnosis. Poor liver function in children can also cause an increase in bilirubin, resulting in a yellowish complexion, which requires blood tests for liver function. In addition, diet can also lead to yellow skin, such as carrots, oranges and other colored foods, which can lead to yellow skin after excessive consumption. Leukemia, also known as “blood cancer”, is mainly caused by the destruction of bone marrow hematopoietic function, which can lead to many diseases, and if it affects the liver and gallbladder dysfunction, resulting in liver disease, then facial yellowing may occur. However, patients with leukemia may also have fever, bleeding gums, nosebleeds, enlarged liver and spleen, etc. Therefore, they can be differentiated by auxiliary tests such as bone marrow aspiration.