Hepatitis B is only in the course of interferon therapy, which has a cure rate of 8-10%. With the development of drugs, nucleoside analogues of drugs have a better control of hepatitis B virus, but to achieve a cure for hepatitis B, there is almost nothing in nucleoside analogues. But in recent years, as the understanding of hepatitis B becomes clearer, for the few patients who have been taking hepatitis B antiviral drugs for a long time, immunotherapy at this time, the hepatitis B cure rate can reach more than 30-40%, especially for the preferential patients. So the cure rate of hepatitis B is now improved, and this is the current treatment guideline for hepatitis B in countries all over the world, with the cure rate of hepatitis B or the cure of hepatitis B as the treatment goal. So now hepatitis B can be clinically cured, it is just a matter of time and the method used, so the cure rate is a broader concept. Patients with hepatitis B are divided into two categories, namely patients treated for the first time and patients who have been treated with nucleoside analogues, or treated patients. The one-year cure rate for first-treatment patients is 16%, but for treated patients, with the right treatment and the right patient, a cure rate of 40% to 60% can be achieved.