Pediatric rectal administration of the most serious harm is due to the process of operation, too much force or improper operation, easy to lead to local mucosal injury, causing rectal or perianal irritation, resulting in bleeding, edema or mucosal irritation caused by the erosion of the situation, this is the rectal administration of the most obvious harm. If for other drugs, such as suppositories for rectal administration, basically the damage is not great. For localized medications, rectal administration of medications is still advocated. This is because pulmonary cough, intestinal inflammatory irritation, infection, etc., for rectal administration of drugs absorbed quickly, and to avoid the digestive system of absorption and first-pass elimination effect. Therefore, rectal administration of drugs should still have more advantages, as long as the operation is appropriate, generally speaking, there is no obvious harm.